Drug interactions
Doxepin + Rocuronium
Severity: Minor
Doxepin and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has anticholinergic and sedative properties, and its clinical effect on rocuronium is small. Any interaction is largely theoretical, with possible additive anticholinergic effects such as tachycardia or sedation perioperatively.
What this interaction means in plain words
Doxepin and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Rocuronium belongs to Musculoskeletal.
Why it happens
Weak additive anticholinergic activity; a clinically meaningful effect on neuromuscular blockade is not well established.
What to do
No dose change is usually needed; monitor heart rate and neuromuscular recovery during anesthesia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Rocuronium?
MediHelp rates the interaction as minor. Doxepin and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxepin has anticholinergic and sedative properties, and its clinical effect on rocuronium is small. Any interaction is largely theoretical, with possible additive anticholinergic effects such as tachycardia or sedation perioperatively.
How serious is the interaction between Doxepin and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor heart rate and neuromuscular recovery during anesthesia.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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