Drug interactions
Doxepin + Salbutamol
Severity: Moderate
Doxepin and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin may enhance the cardiovascular effects of beta-agonists, including tachycardia and arrhythmias. Clinical significance is typically modest with standard inhaled salbutamol doses.
What this interaction means in plain words
Doxepin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Salbutamol belongs to Respiratory.
Why it happens
Additive adrenergic stimulation and cardiac effects from tricyclic norepinephrine reuptake inhibition.
What to do
Monitor heart rate and blood pressure, and watch for palpitations or arrhythmia with frequent or high-dose salbutamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Salbutamol?
MediHelp rates the interaction as moderate. Doxepin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin may enhance the cardiovascular effects of beta-agonists, including tachycardia and arrhythmias. Clinical significance is typically modest with standard inhaled salbutamol doses.
How serious is the interaction between Doxepin and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and watch for palpitations or arrhythmia with frequent or high-dose salbutamol.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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