Drug interactions
Doxepin + Scopolamine
Severity: Moderate
Doxepin and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant with strong anticholinergic and sedating properties, and scopolamine adds to these effects. Together they can cause dry mouth, constipation, urinary retention, tachycardia, blurred vision, confusion and delirium.
What this interaction means in plain words
Doxepin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Scopolamine belongs to Respiratory.
Why it happens
Additive antimuscarinic and sedative effects.
What to do
Monitor for anticholinergic toxicity and CNS effects, particularly in older adults or those with glaucoma, urinary obstruction or ileus. Use the lowest effective doses or choose a less anticholinergic alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Scopolamine?
MediHelp rates the interaction as moderate. Doxepin and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic antidepressant with strong anticholinergic and sedating properties, and scopolamine adds to these effects. Together they can cause dry mouth, constipation, urinary retention, tachycardia, blurred vision, confusion and delirium.
How serious is the interaction between Doxepin and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and CNS effects, particularly in older adults or those with glaucoma, urinary obstruction or ileus. Use the lowest effective doses or choose a less anticholinergic alternative.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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