Drug interactions
Doxepin + Sorafenib
Severity: Moderate
Doxepin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, can prolong the QT interval, particularly at higher doses or in overdose. Together with sorafenib the risk of arrhythmia may be somewhat increased.
What this interaction means in plain words
Doxepin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and keep potassium and magnesium normal. Use the lowest effective doxepin dose and monitor the QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Sorafenib?
MediHelp rates the interaction as moderate. Doxepin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, can prolong the QT interval, particularly at higher doses or in overdose. Together with sorafenib the risk of arrhythmia may be somewhat increased.
How serious is the interaction between Doxepin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and keep potassium and magnesium normal. Use the lowest effective doxepin dose and monitor the QTc.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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