Drug interactions
Doxepin + Sunitinib
Severity: Moderate
Doxepin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval, and doxepin, a tricyclic antidepressant, has also been associated with QT prolongation and arrhythmia at higher exposures. Combining them may raise the risk of ventricular arrhythmias including torsades de pointes, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Doxepin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc periodically, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Sunitinib?
MediHelp rates the interaction as moderate. Doxepin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib can prolong the QT interval, and doxepin, a tricyclic antidepressant, has also been associated with QT prolongation and arrhythmia at higher exposures. Combining them may raise the risk of ventricular arrhythmias including torsades de pointes, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Doxepin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if QTc rises markedly.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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