Drug interactions
Doxorubicin + Dronedarone
Severity: Moderate
Doxorubicin and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is a substrate of P-glycoprotein and CYP3A4, both of which dronedarone inhibits. Higher doxorubicin exposure may worsen myelosuppression and cardiotoxicity, which is particularly relevant in a patient with arrhythmia.
What this interaction means in plain words
Doxorubicin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Dronedarone belongs to Cardiovascular.
Why it happens
Dronedarone inhibits P-glycoprotein efflux and CYP3A4, decreasing doxorubicin elimination.
What to do
Monitor blood counts and cardiac function (ECG, and LVEF as indicated) during therapy. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Dronedarone?
MediHelp rates the interaction as moderate. Doxorubicin and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxorubicin is a substrate of P-glycoprotein and CYP3A4, both of which dronedarone inhibits. Higher doxorubicin exposure may worsen myelosuppression and cardiotoxicity, which is particularly relevant in a patient with arrhythmia.
How serious is the interaction between Doxorubicin and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function (ECG, and LVEF as indicated) during therapy. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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