Drug interactions
Doxorubicin + Eliglustat
Severity: Moderate
Doxorubicin and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and CYP2D6, both of which contribute to doxorubicin disposition. Doxorubicin exposure and toxicity may increase.
What this interaction means in plain words
Doxorubicin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits P-gp efflux and CYP2D6, possibly reducing doxorubicin clearance.
What to do
Monitor blood counts and cardiac function. Reduce the doxorubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Doxorubicin with Eliglustat?
MediHelp rates the interaction as moderate. Doxorubicin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and CYP2D6, both of which contribute to doxorubicin disposition. Doxorubicin exposure and toxicity may increase.
How serious is the interaction between Doxorubicin and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function. Reduce the doxorubicin dose if toxicity develops.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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