Drug interactions
Doxorubicin + Etravirine
Severity: Moderate
Doxorubicin and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower doxorubicin exposure, potentially reducing efficacy. Its effect on P-gp is minor and the interaction is predicted rather than well documented.
What this interaction means in plain words
Doxorubicin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4, increasing doxorubicin metabolism.
What to do
Monitor tumor response and toxicity. Coordinate with HIV specialists about alternatives if efficacy is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Doxorubicin with Etravirine?
MediHelp rates the interaction as moderate. Doxorubicin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower doxorubicin exposure, potentially reducing efficacy. Its effect on P-gp is minor and the interaction is predicted rather than well documented.
How serious is the interaction between Doxorubicin and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and toxicity. Coordinate with HIV specialists about alternatives if efficacy is a concern.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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