Drug interactions
Doxorubicin + Fosaprepitant
Severity: Minor
Doxorubicin and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which could modestly raise exposure to doxorubicin. Doxorubicin is only partly cleared by CYP3A4, and in practice the combination is commonly given within antiemetic regimens without clear harm.
What this interaction means in plain words
Doxorubicin and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant weakly to moderately inhibits CYP3A4, which may slightly reduce doxorubicin metabolism.
What to do
No dose change is usually needed; monitor for enhanced myelosuppression and mucositis during chemotherapy cycles.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Doxorubicin with Fosaprepitant?
MediHelp rates the interaction as minor. Doxorubicin and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor, which could modestly raise exposure to doxorubicin. Doxorubicin is only partly cleared by CYP3A4, and in practice the combination is commonly given within antiemetic regimens without clear harm.
How serious is the interaction between Doxorubicin and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor for enhanced myelosuppression and mucositis during chemotherapy cycles.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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