Drug interactions
Doxorubicin + Hydroxycarbamide
Severity: Moderate
Doxorubicin and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow, so combined use can deepen neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding and may require delays or dose reductions.
What this interaction means in plain words
Doxorubicin and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppression from two cytotoxic agents.
What to do
Monitor complete blood counts regularly and adjust doses or delay cycles for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Doxorubicin with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Doxorubicin and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow, so combined use can deepen neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding and may require delays or dose reductions.
How serious is the interaction between Doxorubicin and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay cycles for significant cytopenias.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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