Drug interactions
Doxorubicin + Iloperidone
Severity: Moderate
Doxorubicin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is a weak CYP3A4 inhibitor and may slightly raise doxorubicin concentrations. Clinical significance is likely small, but both agents can affect the heart, with iloperidone prolonging the QT interval.
What this interaction means in plain words
Doxorubicin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Iloperidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by iloperidone plus additive cardiac effects (QT prolongation with anthracycline cardiotoxicity).
What to do
Obtain a baseline ECG and monitor QTc and cardiac function during treatment; correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Doxorubicin with Iloperidone?
MediHelp rates the interaction as moderate. Doxorubicin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is a weak CYP3A4 inhibitor and may slightly raise doxorubicin concentrations. Clinical significance is likely small, but both agents can affect the heart, with iloperidone prolonging the QT interval.
How serious is the interaction between Doxorubicin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and cardiac function during treatment; correct potassium and magnesium abnormalities.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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