Drug interactions
Doxorubicin + Ivacaftor
Severity: Minor
Doxorubicin and Ivacaftor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-gp and may modestly increase doxorubicin exposure. The clinical effect is unlikely to be large but could add to anthracycline toxicity.
What this interaction means in plain words
Doxorubicin and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor and its M1 metabolite inhibit P-gp-mediated efflux.
What to do
No routine dose change; monitor blood counts and cardiac function as usual during doxorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Doxorubicin with Ivacaftor?
MediHelp rates the interaction as minor. Doxorubicin and Ivacaftor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ivacaftor weakly inhibits P-gp and may modestly increase doxorubicin exposure. The clinical effect is unlikely to be large but could add to anthracycline toxicity.
How serious is the interaction between Doxorubicin and Ivacaftor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor blood counts and cardiac function as usual during doxorubicin therapy.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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