Drug interactions
Doxorubicin + Lasmiditan
Severity: Minor
Doxorubicin and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein and BCRP in vitro, which could increase doxorubicin exposure. Clinical relevance is unclear, as lasmiditan is taken intermittently for migraine.
What this interaction means in plain words
Doxorubicin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits P-gp and BCRP efflux transporters, potentially increasing doxorubicin levels.
What to do
No routine adjustment is required. Monitor for increased doxorubicin toxicity if lasmiditan is used frequently.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxorubicin and Lasmiditan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxorubicin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Doxorubicin with Lasmiditan?
MediHelp rates the interaction as minor. Doxorubicin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits P-glycoprotein and BCRP in vitro, which could increase doxorubicin exposure. Clinical relevance is unclear, as lasmiditan is taken intermittently for migraine.
How serious is the interaction between Doxorubicin and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is required. Monitor for increased doxorubicin toxicity if lasmiditan is used frequently.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
