Drug interactions
Doxorubicin + Lonafarnib
Severity: Moderate
Doxorubicin and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may raise doxorubicin exposure, increasing myelosuppression and cardiotoxicity. The listed direction, doxorubicin raising lonafarnib, is unlikely since doxorubicin is not a meaningful CYP3A inhibitor.
What this interaction means in plain words
Doxorubicin and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibits CYP3A4, potentially reducing doxorubicin metabolism.
What to do
Monitor blood counts, ECG and cardiac function during co-administration. Consider doxorubicin dose reduction if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Doxorubicin with Lonafarnib?
MediHelp rates the interaction as moderate. Doxorubicin and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may raise doxorubicin exposure, increasing myelosuppression and cardiotoxicity. The listed direction, doxorubicin raising lonafarnib, is unlikely since doxorubicin is not a meaningful CYP3A inhibitor.
How serious is the interaction between Doxorubicin and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, ECG and cardiac function during co-administration. Consider doxorubicin dose reduction if toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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