Drug interactions
Doxorubicin + Midazolam
Severity: Minor
Doxorubicin and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxorubicin is not a recognised clinically significant CYP3A4 inhibitor, so a meaningful increase in midazolam levels is not expected. Any interaction is theoretical.
What this interaction means in plain words
Doxorubicin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Midazolam belongs to Central Nervous System.
Why it happens
No established mechanism; doxorubicin is a minor CYP3A4 substrate.
What to do
No adjustment needed; use standard midazolam titration and monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Doxorubicin
Frequently asked questions
Can I take Doxorubicin with Midazolam?
MediHelp rates the interaction as minor. Doxorubicin and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxorubicin is not a recognised clinically significant CYP3A4 inhibitor, so a meaningful increase in midazolam levels is not expected. Any interaction is theoretical.
How serious is the interaction between Doxorubicin and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; use standard midazolam titration and monitoring.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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