Drug interactions
Doxorubicin + Ribociclib
Severity: Moderate
Doxorubicin and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4 and P-gp, which may modestly increase doxorubicin exposure. Both drugs can also affect cardiac function, ribociclib via QT prolongation and doxorubicin via cardiomyopathy and arrhythmia, and both cause neutropenia.
What this interaction means in plain words
Doxorubicin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-gp by ribociclib, plus additive cardiac and myelosuppressive effects.
What to do
Monitor blood counts, ECG and cardiac function during co-treatment. Correct electrolytes and consider doxorubicin dose adjustment if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Doxorubicin with Ribociclib?
MediHelp rates the interaction as moderate. Doxorubicin and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4 and P-gp, which may modestly increase doxorubicin exposure. Both drugs can also affect cardiac function, ribociclib via QT prolongation and doxorubicin via cardiomyopathy and arrhythmia, and both cause neutropenia.
How serious is the interaction between Doxorubicin and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, ECG and cardiac function during co-treatment. Correct electrolytes and consider doxorubicin dose adjustment if toxicity occurs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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