Drug interactions
Doxorubicin + Tazemetostat
Severity: Minor
Doxorubicin and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and is itself a CYP3A4 substrate. Effects on doxorubicin are expected to be small because CYP3A4 is a minor route of its clearance. Overall clinical significance is probably limited.
What this interaction means in plain words
Doxorubicin and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Tazemetostat weakly induces CYP3A4, and doxorubicin may have a minor effect on tazemetostat metabolism.
What to do
No dose adjustment is generally needed; monitor for efficacy and tolerability of both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Tazemetostat
Frequently asked questions
Can I take Doxorubicin with Tazemetostat?
MediHelp rates the interaction as minor. Doxorubicin and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and is itself a CYP3A4 substrate. Effects on doxorubicin are expected to be small because CYP3A4 is a minor route of its clearance. Overall clinical significance is probably limited.
How serious is the interaction between Doxorubicin and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for efficacy and tolerability of both drugs.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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