Drug interactions
Doxorubicin + Tecovirimat
Severity: Minor
Doxorubicin and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP3A4 inducer and could modestly lower exposure to CYP3A4 substrates. Doxorubicin depends only partly on CYP3A4, so a meaningful loss of effect is unlikely. Short tecovirimat courses further limit the impact.
What this interaction means in plain words
Doxorubicin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxorubicin belongs to Oncology; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tecovirimat may slightly increase doxorubicin metabolism.
What to do
No adjustment is usually needed; monitor clinical response to doxorubicin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxorubicin
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Doxorubicin with Tecovirimat?
MediHelp rates the interaction as minor. Doxorubicin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP3A4 inducer and could modestly lower exposure to CYP3A4 substrates. Doxorubicin depends only partly on CYP3A4, so a meaningful loss of effect is unlikely. Short tecovirimat courses further limit the impact.
How serious is the interaction between Doxorubicin and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; monitor clinical response to doxorubicin.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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