Drug interactions
Doxorubicin + Tipranavir
Severity: Moderate
Doxorubicin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir has mixed CYP3A4 effects but inhibits CYP3A4 and P-gp overall, and may alter doxorubicin exposure unpredictably. Both agents can produce hematologic and hepatic toxicity.
What this interaction means in plain words
Doxorubicin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir modulates CYP3A4 and P-gp, altering doxorubicin clearance.
What to do
Prefer a different antiretroviral during doxorubicin therapy. If combined, monitor blood counts, liver tests and cardiac function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Doxorubicin with Tipranavir?
MediHelp rates the interaction as moderate. Doxorubicin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir has mixed CYP3A4 effects but inhibits CYP3A4 and P-gp overall, and may alter doxorubicin exposure unpredictably. Both agents can produce hematologic and hepatic toxicity.
How serious is the interaction between Doxorubicin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a different antiretroviral during doxorubicin therapy. If combined, monitor blood counts, liver tests and cardiac function.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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