Drug interactions
Doxorubicin + Vemurafenib
Severity: Moderate
Doxorubicin and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase systemic exposure to doxorubicin. This might increase myelosuppression and cardiotoxicity. Evidence is largely from in vitro and labeling-based predictions.
What this interaction means in plain words
Doxorubicin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxorubicin belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-gp, reducing efflux of doxorubicin.
What to do
Monitor blood counts and cardiac function, and consider reducing the doxorubicin dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Vemurafenib
Frequently asked questions
Can I take Doxorubicin with Vemurafenib?
MediHelp rates the interaction as moderate. Doxorubicin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase systemic exposure to doxorubicin. This might increase myelosuppression and cardiotoxicity. Evidence is largely from in vitro and labeling-based predictions.
How serious is the interaction between Doxorubicin and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider reducing the doxorubicin dose if toxicity appears.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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