Drug interactions
Doxorubicin liposomal + Dronedarone
Severity: Moderate
Doxorubicin liposomal and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and P-glycoprotein, both involved in doxorubicin disposition, so exposure to doxorubicin may rise. This could increase myelosuppression, mucositis and cardiotoxicity.
What this interaction means in plain words
Doxorubicin liposomal and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of P-glycoprotein efflux and CYP3A4 may increase doxorubicin exposure.
What to do
Monitor blood counts and cardiac function, and consider an alternative antiarrhythmic if feasible. Reduce chemotherapy dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Dronedarone?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and P-glycoprotein, both involved in doxorubicin disposition, so exposure to doxorubicin may rise. This could increase myelosuppression, mucositis and cardiotoxicity.
How serious is the interaction between Doxorubicin liposomal and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and consider an alternative antiarrhythmic if feasible. Reduce chemotherapy dose if toxicity appears.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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