Drug interactions
Doxorubicin liposomal + Ribociclib
Severity: Moderate
Doxorubicin liposomal and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib may increase exposure to doxorubicin, which carries cardiotoxicity and myelosuppression risks. The effect on the liposomal form is less certain but possible.
What this interaction means in plain words
Doxorubicin liposomal and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4 and possibly P-glycoprotein, which may reduce doxorubicin clearance.
What to do
Monitor blood counts and cardiac function and watch for increased toxicity. Consider dose adjustment if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Ribociclib?
MediHelp rates the interaction as moderate. Doxorubicin liposomal and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib may increase exposure to doxorubicin, which carries cardiotoxicity and myelosuppression risks. The effect on the liposomal form is less certain but possible.
How serious is the interaction between Doxorubicin liposomal and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function and watch for increased toxicity. Consider dose adjustment if toxicity appears.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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