Drug interactions
Doxorubicin liposomal + Tacrolimus
Severity: Minor
Doxorubicin liposomal and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may inhibit P-gp and theoretically increase doxorubicin exposure. Liposomal formulation has altered distribution, so the clinical impact is uncertain.
What this interaction means in plain words
Doxorubicin liposomal and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-gp inhibition by tacrolimus; not well established for the liposomal form.
What to do
No specific adjustment is required; monitor for myelosuppression and cardiotoxicity as per routine doxorubicin care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Doxorubicin liposomal with Tacrolimus?
MediHelp rates the interaction as minor. Doxorubicin liposomal and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may inhibit P-gp and theoretically increase doxorubicin exposure. Liposomal formulation has altered distribution, so the clinical impact is uncertain.
How serious is the interaction between Doxorubicin liposomal and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is required; monitor for myelosuppression and cardiotoxicity as per routine doxorubicin care.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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