Drug interactions
Doxycycline + Entrectinib
Severity: Minor
Doxycycline and Entrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxycycline is not a recognized clinically relevant CYP3A4 inhibitor, so a meaningful rise in entrectinib exposure is unlikely. Entrectinib toxicities such as QT prolongation and CNS effects would be the concern if exposure increased.
What this interaction means in plain words
Doxycycline and Entrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Entrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition, not established for doxycycline.
What to do
No empiric dose reduction is needed; monitor for entrectinib adverse effects including QT interval if other risk factors exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Entrectinib
Frequently asked questions
Can I take Doxycycline with Entrectinib?
MediHelp rates the interaction as minor. Doxycycline and Entrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxycycline is not a recognized clinically relevant CYP3A4 inhibitor, so a meaningful rise in entrectinib exposure is unlikely. Entrectinib toxicities such as QT prolongation and CNS effects would be the concern if exposure increased.
How serious is the interaction between Doxycycline and Entrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose reduction is needed; monitor for entrectinib adverse effects including QT interval if other risk factors exist.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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