Drug interactions
Doxycycline + Mavacamten
Severity: Minor
Doxycycline and Mavacamten: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 and CYP3A4, and its exposure can rise with enzyme inhibitors, increasing the risk of excessive reduction in ejection fraction and heart failure. Doxycycline is not a recognized meaningful CYP3A4 inhibitor, so the effect, if any, is likely small.
What this interaction means in plain words
Doxycycline and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by doxycycline is theoretical and not well established clinically.
What to do
No empirical dose change is needed; monitor LVEF and clinical status per the mavacamten REMS schedule when starting or stopping any interacting drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxycycline and Mavacamten, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Doxycycline with Mavacamten?
MediHelp rates the interaction as minor. Doxycycline and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mavacamten is cleared mainly by CYP2C19 and CYP3A4, and its exposure can rise with enzyme inhibitors, increasing the risk of excessive reduction in ejection fraction and heart failure. Doxycycline is not a recognized meaningful CYP3A4 inhibitor, so the effect, if any, is likely small.
How serious is the interaction between Doxycycline and Mavacamten?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor LVEF and clinical status per the mavacamten REMS schedule when starting or stopping any interacting drug.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
