Drug interactions
Doxycycline + Norgestrel
Severity: Minor
Doxycycline and Norgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norgestrel is partly cleared by CYP3A4, but doxycycline is not a clinically relevant CYP3A4 inhibitor. A meaningful rise in progestin exposure is not expected, and doxycycline has not been shown to reduce the efficacy of hormonal contraceptives.
What this interaction means in plain words
Doxycycline and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Norgestrel belongs to Endocrine.
Why it happens
Theoretical CYP3A4 inhibition by doxycycline that is not demonstrated clinically.
What to do
No adjustment is required. Counsel the patient to report unusual hormonal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Norgestrel
- Amobarbital + Norgestrel Major
- Apalutamide + Norgestrel Major
- Bosentan + Norgestrel Major
- Carbamazepine + Norgestrel Major
- Efavirenz + Norgestrel Major
- Enzalutamide + Norgestrel Major
Frequently asked questions
Can I take Doxycycline with Norgestrel?
MediHelp rates the interaction as minor. Doxycycline and Norgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Norgestrel is partly cleared by CYP3A4, but doxycycline is not a clinically relevant CYP3A4 inhibitor. A meaningful rise in progestin exposure is not expected, and doxycycline has not been shown to reduce the efficacy of hormonal contraceptives.
How serious is the interaction between Doxycycline and Norgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Counsel the patient to report unusual hormonal adverse effects.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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