Drug interactions
Doxycycline + Suvorexant
Severity: Minor
Doxycycline and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is cleared mainly by CYP3A4, and inhibitors can increase next-day somnolence and impaired driving. Doxycycline is not a known meaningful CYP3A4 inhibitor, so the interaction is probably of little clinical consequence.
What this interaction means in plain words
Doxycycline and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Suvorexant belongs to Central Nervous System.
Why it happens
Theoretical CYP3A4 inhibition by doxycycline could modestly raise suvorexant exposure.
What to do
Use the usual suvorexant dose and ask the patient about next-day drowsiness; reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Suvorexant
Frequently asked questions
Can I take Doxycycline with Suvorexant?
MediHelp rates the interaction as minor. Doxycycline and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Suvorexant is cleared mainly by CYP3A4, and inhibitors can increase next-day somnolence and impaired driving. Doxycycline is not a known meaningful CYP3A4 inhibitor, so the interaction is probably of little clinical consequence.
How serious is the interaction between Doxycycline and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the usual suvorexant dose and ask the patient about next-day drowsiness; reduce the dose if excessive sedation occurs.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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