Drug interactions
Doxycycline + Trabectedin
Severity: Minor
Doxycycline and Trabectedin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trabectedin is mainly metabolized by CYP3A4, and strong inhibitors can increase its toxicity. Doxycycline is not a significant CYP3A4 inhibitor, so a clinically relevant effect is unlikely, though trabectedin is hepatotoxic.
What this interaction means in plain words
Doxycycline and Trabectedin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Trabectedin belongs to Oncology.
Why it happens
Theoretical CYP3A4 inhibition by doxycycline that is not established.
What to do
No dose change is required. Continue routine liver enzyme and CK monitoring for trabectedin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Trabectedin
Frequently asked questions
Can I take Doxycycline with Trabectedin?
MediHelp rates the interaction as minor. Doxycycline and Trabectedin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trabectedin is mainly metabolized by CYP3A4, and strong inhibitors can increase its toxicity. Doxycycline is not a significant CYP3A4 inhibitor, so a clinically relevant effect is unlikely, though trabectedin is hepatotoxic.
How serious is the interaction between Doxycycline and Trabectedin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Continue routine liver enzyme and CK monitoring for trabectedin.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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