Drug interactions
Doxylamine + Loxapine
Severity: Moderate
Doxylamine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine with strong anticholinergic properties, often used as a sleep aid. With loxapine it can cause excessive sedation, next-day impairment and additive anticholinergic effects.
What this interaction means in plain words
Doxylamine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and antimuscarinic effects from H1 antagonism and antipsychotic receptor blockade.
What to do
Advise against combining with other sedatives and avoid driving or hazardous tasks. Consider a non-sedating alternative and monitor older patients for confusion and urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Loxapine?
MediHelp rates the interaction as moderate. Doxylamine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine with strong anticholinergic properties, often used as a sleep aid. With loxapine it can cause excessive sedation, next-day impairment and additive anticholinergic effects.
How serious is the interaction between Doxylamine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against combining with other sedatives and avoid driving or hazardous tasks. Consider a non-sedating alternative and monitor older patients for confusion and urinary retention.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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