Drug interactions
Doxylamine + Maprotiline
Severity: Moderate
Doxylamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating, anticholinergic antihistamine, and maprotiline adds similar effects. Together they may cause pronounced drowsiness, impaired alertness and anticholinergic symptoms such as dry mouth, constipation and urinary retention.
What this interaction means in plain words
Doxylamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive H1 antihistaminic CNS depression and additive anticholinergic activity.
What to do
Counsel against driving and alcohol use, and avoid routine use of doxylamine for sleep alongside maprotiline in older adults. Reduce the dose or stop doxylamine if daytime sedation or anticholinergic effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Maprotiline?
MediHelp rates the interaction as moderate. Doxylamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating, anticholinergic antihistamine, and maprotiline adds similar effects. Together they may cause pronounced drowsiness, impaired alertness and anticholinergic symptoms such as dry mouth, constipation and urinary retention.
How serious is the interaction between Doxylamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel against driving and alcohol use, and avoid routine use of doxylamine for sleep alongside maprotiline in older adults. Reduce the dose or stop doxylamine if daytime sedation or anticholinergic effects appear.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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