Drug interactions
Doxylamine + Metaxalone
Severity: Moderate
Doxylamine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine, often taken as a sleep aid, and it can add to the sedative effect of metaxalone. This may cause marked drowsiness, slowed reaction time and next-day impairment.
What this interaction means in plain words
Doxylamine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression through pharmacodynamic synergy.
What to do
Advise the patient to avoid driving or hazardous tasks while taking both. Recommend avoiding the combination in older adults or using a lower doxylamine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Metaxalone?
MediHelp rates the interaction as moderate. Doxylamine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine, often taken as a sleep aid, and it can add to the sedative effect of metaxalone. This may cause marked drowsiness, slowed reaction time and next-day impairment.
How serious is the interaction between Doxylamine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to avoid driving or hazardous tasks while taking both. Recommend avoiding the combination in older adults or using a lower doxylamine dose.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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