Drug interactions
Doxylamine + Nalbuphine
Severity: Moderate
Doxylamine and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine and increases the drowsiness and psychomotor impairment caused by nalbuphine. Falls and confusion are a particular risk in older people.
What this interaction means in plain words
Doxylamine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid activity and central H1-antihistamine effects.
What to do
Avoid unnecessary co-use and keep doses low if both are needed. Monitor sedation and counsel on avoiding driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Nalbuphine?
MediHelp rates the interaction as moderate. Doxylamine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine and increases the drowsiness and psychomotor impairment caused by nalbuphine. Falls and confusion are a particular risk in older people.
How serious is the interaction between Doxylamine and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary co-use and keep doses low if both are needed. Monitor sedation and counsel on avoiding driving.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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