Drug interactions
Doxylamine + Oliceridine
Severity: Major
Doxylamine and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, coma and death. Doxylamine adds sedative effects to oliceridine and can heighten this risk.
What this interaction means in plain words
Doxylamine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxylamine belongs to Respiratory; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid agonism plus sedating antihistamine effects.
What to do
Reserve the combination for patients who lack alternatives, using the lowest doses for the shortest duration. Monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Doxylamine
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Doxylamine with Oliceridine?
MediHelp rates the interaction as major. Doxylamine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, coma and death. Doxylamine adds sedative effects to oliceridine and can heighten this risk.
How serious is the interaction between Doxylamine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients who lack alternatives, using the lowest doses for the shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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