Drug interactions
Doxylamine + Ramelteon
Severity: Moderate
Doxylamine and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine that may amplify ramelteon-induced drowsiness. This raises the risk of next-day impairment, confusion and falls.
What this interaction means in plain words
Doxylamine and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Ramelteon belongs to Central Nervous System.
Why it happens
Additive sedation from melatonin receptor agonism and central H1 antihistamine blockade.
What to do
Avoid combining two sleep aids when possible and counsel about driving and fall risk. Use the lowest effective dose of each if both are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Ramelteon?
MediHelp rates the interaction as moderate. Doxylamine and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine that may amplify ramelteon-induced drowsiness. This raises the risk of next-day impairment, confusion and falls.
How serious is the interaction between Doxylamine and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two sleep aids when possible and counsel about driving and fall risk. Use the lowest effective dose of each if both are needed.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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