Drug interactions
Doxylamine + Sufentanil
Severity: Major
Doxylamine and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid, and sedating antihistamines add to its depressant effects. The combination may cause deeper sedation and respiratory depression.
What this interaction means in plain words
Doxylamine and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Doxylamine belongs to Respiratory; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
What to do
Titrate sufentanil carefully and reduce doses as needed. Continuously monitor respiration and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Doxylamine
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Doxylamine with Sufentanil?
MediHelp rates the interaction as major. Doxylamine and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a very potent opioid, and sedating antihistamines add to its depressant effects. The combination may cause deeper sedation and respiratory depression.
How serious is the interaction between Doxylamine and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil carefully and reduce doses as needed. Continuously monitor respiration and sedation.
What other medicines interact with Doxylamine?
MediHelp also lists interactions of Doxylamine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Doxylamine page.
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