Drug interactions
Dronabinol + Fluorouracil
Severity: Minor
Dronabinol and Fluorouracil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is metabolized by CYP2C9, and fluorouracil has been reported to affect this pathway, which could raise dronabinol exposure. Higher levels may cause more sedation, dizziness, tachycardia or confusion.
What this interaction means in plain words
Dronabinol and Fluorouracil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronabinol belongs to Central Nervous System; Fluorouracil belongs to Oncology.
Why it happens
Possible inhibition of CYP2C9-mediated dronabinol metabolism; the effect is predicted rather than well established.
What to do
Monitor for excessive sedation, cognitive effects and tachycardia. Lower the dronabinol dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluorouracil
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Fluorouracil?
MediHelp rates the interaction as minor. Dronabinol and Fluorouracil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronabinol is metabolized by CYP2C9, and fluorouracil has been reported to affect this pathway, which could raise dronabinol exposure. Higher levels may cause more sedation, dizziness, tachycardia or confusion.
How serious is the interaction between Dronabinol and Fluorouracil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, cognitive effects and tachycardia. Lower the dronabinol dose if adverse effects appear.
What other medicines interact with Fluorouracil?
MediHelp also lists interactions of Fluorouracil with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Fluorouracil page.
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