Drug interactions
Dronabinol + Lumacaftor / ivacaftor
Severity: Moderate
Dronabinol and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is a strong CYP3A inducer and may lower dronabinol concentrations. This may reduce its antiemetic or appetite-stimulating benefit.
What this interaction means in plain words
Dronabinol and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induces CYP3A4, increasing the metabolic clearance of dronabinol.
What to do
Monitor for reduced antiemetic or appetite effect and titrate dronabinol upward if needed. Recheck the dose if lumacaftor/ivacaftor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Dronabinol and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is a strong CYP3A inducer and may lower dronabinol concentrations. This may reduce its antiemetic or appetite-stimulating benefit.
How serious is the interaction between Dronabinol and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic or appetite effect and titrate dronabinol upward if needed. Recheck the dose if lumacaftor/ivacaftor is stopped.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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