Drug interactions
Dronabinol + Metoclopramide intranasal
Severity: Moderate
Dronabinol and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect the central nervous system, and metoclopramide can cause drowsiness, dizziness and extrapyramidal effects. Dronabinol can add to sedation and psychomotor impairment, though the interaction is mainly predicted.
What this interaction means in plain words
Dronabinol and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system effects; no specific pharmacokinetic mechanism is established.
What to do
Counsel patients about additive drowsiness and avoid driving until response is known. Monitor for sedation and movement disorders and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Dronabinol and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can affect the central nervous system, and metoclopramide can cause drowsiness, dizziness and extrapyramidal effects. Dronabinol can add to sedation and psychomotor impairment, though the interaction is mainly predicted.
How serious is the interaction between Dronabinol and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving until response is known. Monitor for sedation and movement disorders and reduce doses if they occur.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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