Drug interactions
Dronabinol + Nefazodone
Severity: Moderate
Dronabinol and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may raise dronabinol levels. This can increase sedation, dizziness, tachycardia and mood or cognitive disturbance, and both drugs also have CNS effects.
What this interaction means in plain words
Dronabinol and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing dronabinol clearance, with additive CNS effects.
What to do
Use a lower starting dose of dronabinol and monitor for sedation and psychiatric effects. Titrate slowly based on tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Nefazodone?
MediHelp rates the interaction as moderate. Dronabinol and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and may raise dronabinol levels. This can increase sedation, dizziness, tachycardia and mood or cognitive disturbance, and both drugs also have CNS effects.
How serious is the interaction between Dronabinol and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower starting dose of dronabinol and monitor for sedation and psychiatric effects. Titrate slowly based on tolerability.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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