Drug interactions
Dronabinol + Sulfamethoxazole
Severity: Minor
Dronabinol and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9 and might modestly increase dronabinol concentrations. The clinical effect is probably small.
What this interaction means in plain words
Dronabinol and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfamethoxazole inhibits CYP2C9, slightly reducing dronabinol clearance.
What to do
No routine dose change is needed. Monitor for increased sedation or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Sulfamethoxazole?
MediHelp rates the interaction as minor. Dronabinol and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole inhibits CYP2C9 and might modestly increase dronabinol concentrations. The clinical effect is probably small.
How serious is the interaction between Dronabinol and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased sedation or dizziness.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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