Drug interactions
Dronedarone + Droperidol
Severity: Contraindicated
Dronedarone and Droperidol: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use markedly raises the risk of life-threatening arrhythmia.
What this interaction means in plain words
Dronedarone and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive blockade of cardiac potassium channels with QT prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antiemetic or sedative such as one from another class.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Droperidol?
MediHelp rates the interaction as contraindicated. Dronedarone and Droperidol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and droperidol carries a boxed warning for torsades de pointes. Combined use markedly raises the risk of life-threatening arrhythmia.
How serious is the interaction between Dronedarone and Droperidol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antiemetic or sedative such as one from another class.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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