Drug interactions
Dronedarone + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Contraindicated
Dronedarone and Elvitegravir / cobicistat / emtricitabine / tenofovir df: contraindicated interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A4 inhibitor and is expected to raise dronedarone levels considerably. Higher exposure increases the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Dronedarone and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Cobicistat inhibits CYP3A4, reducing dronedarone clearance.
What to do
Do not use together; choose a non-boosted antiretroviral regimen or a different antiarrhythmic.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
- Dronedarone 400 mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: potent CYP 3A4 inhibitors; "concomitant use of ketoconazole as well as other potent CYP 3A4 inhibitors such as itraconazole, voriconazole, pozaconazole, ritonavir, telithromycin, clarithro") — electronic medicines compendium (UK SmPC)
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as contraindicated. Dronedarone and Elvitegravir / cobicistat / emtricitabine / tenofovir df are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor and is expected to raise dronedarone levels considerably. Higher exposure increases the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Dronedarone and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose a non-boosted antiretroviral regimen or a different antiarrhythmic.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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