Drug interactions
Dronedarone + Epinephrine
Severity: Moderate
Dronedarone and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epinephrine can provoke arrhythmias and has QT-related effects, and dronedarone also alters conduction and repolarization. In emergencies such as anaphylaxis, epinephrine should not be withheld, but arrhythmia risk is raised.
What this interaction means in plain words
Dronedarone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Additive proarrhythmic effects from adrenergic stimulation and dronedarone repolarization effects.
What to do
Use epinephrine when clearly indicated, with ECG monitoring. Avoid non-essential epinephrine, such as in local anesthetic combinations in large doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Dronedarone with Epinephrine?
MediHelp rates the interaction as moderate. Dronedarone and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epinephrine can provoke arrhythmias and has QT-related effects, and dronedarone also alters conduction and repolarization. In emergencies such as anaphylaxis, epinephrine should not be withheld, but arrhythmia risk is raised.
How serious is the interaction between Dronedarone and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use epinephrine when clearly indicated, with ECG monitoring. Avoid non-essential epinephrine, such as in local anesthetic combinations in large doses.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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