Drug interactions
Dronedarone + Etoposide
Severity: Moderate
Dronedarone and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etoposide is handled by CYP3A4 and P-glycoprotein, both inhibited by dronedarone. Higher etoposide exposure may intensify myelosuppression and mucositis.
What this interaction means in plain words
Dronedarone and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronedarone belongs to Cardiovascular; Etoposide belongs to Oncology.
Why it happens
Dronedarone inhibits CYP3A4 and P-glycoprotein, decreasing etoposide elimination and increasing absorption.
What to do
Monitor complete blood counts closely and reduce the etoposide dose if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Frequently asked questions
Can I take Dronedarone with Etoposide?
MediHelp rates the interaction as moderate. Dronedarone and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etoposide is handled by CYP3A4 and P-glycoprotein, both inhibited by dronedarone. Higher etoposide exposure may intensify myelosuppression and mucositis.
How serious is the interaction between Dronedarone and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and reduce the etoposide dose if marked myelosuppression occurs.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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