Drug interactions
Dronedarone + Fentanyl transmucosal
Severity: Moderate
Dronedarone and Fentanyl transmucosal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and can raise fentanyl exposure, partly via swallowed drug and delayed clearance. This increases the risk of excessive sedation and respiratory depression.
What this interaction means in plain words
Dronedarone and Fentanyl transmucosal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 metabolism of fentanyl.
What to do
Monitor frequently for sedation and respiratory depression, and titrate fentanyl cautiously with dose reduction if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Fentanyl transmucosal?
MediHelp rates the interaction as moderate. Dronedarone and Fentanyl transmucosal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits CYP3A4 and can raise fentanyl exposure, partly via swallowed drug and delayed clearance. This increases the risk of excessive sedation and respiratory depression.
How serious is the interaction between Dronedarone and Fentanyl transmucosal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor frequently for sedation and respiratory depression, and titrate fentanyl cautiously with dose reduction if needed.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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