Drug interactions
Dronedarone + Fexinidazole
Severity: Contraindicated
Dronedarone and Fexinidazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and fexinidazole may also raise dronedarone levels through CYP3A4 inhibition. Together they increase the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Dronedarone and Fexinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition raising dronedarone exposure.
What to do
Avoid the combination. Use alternative therapy or withhold dronedarone under specialist supervision with ECG and electrolyte monitoring.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Fexinidazole?
MediHelp rates the interaction as contraindicated. Dronedarone and Fexinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and fexinidazole may also raise dronedarone levels through CYP3A4 inhibition. Together they increase the risk of serious ventricular arrhythmia.
How serious is the interaction between Dronedarone and Fexinidazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Use alternative therapy or withhold dronedarone under specialist supervision with ECG and electrolyte monitoring.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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