Drug interactions
Dronedarone + Glecaprevir / pibrentasvir
Severity: Minor
Dronedarone and Glecaprevir / pibrentasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits P-glycoprotein and may raise exposure to glecaprevir and pibrentasvir, which are P-gp substrates. The increase is probably modest and these agents are generally well tolerated.
What this interaction means in plain words
Dronedarone and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein increases absorption of glecaprevir and pibrentasvir.
What to do
No dose adjustment is generally needed; monitor liver tests and tolerability during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Glecaprevir / pibrentasvir?
MediHelp rates the interaction as minor. Dronedarone and Glecaprevir / pibrentasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone inhibits P-glycoprotein and may raise exposure to glecaprevir and pibrentasvir, which are P-gp substrates. The increase is probably modest and these agents are generally well tolerated.
How serious is the interaction between Dronedarone and Glecaprevir / pibrentasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor liver tests and tolerability during treatment.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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