Drug interactions
Dronedarone + Glimepiride-pioglitazone
Severity: Minor
Dronedarone and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone is a moderate CYP3A4 inhibitor and may modestly raise pioglitazone exposure, as pioglitazone is partly metabolised by CYP2C8 and CYP3A4. The clinical effect is expected to be small.
What this interaction means in plain words
Dronedarone and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated pioglitazone metabolism by dronedarone.
What to do
No dose change is normally needed; monitor for edema and glycemic response if both are used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Dronedarone and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone is a moderate CYP3A4 inhibitor and may modestly raise pioglitazone exposure, as pioglitazone is partly metabolised by CYP2C8 and CYP3A4. The clinical effect is expected to be small.
How serious is the interaction between Dronedarone and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for edema and glycemic response if both are used long term.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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