Drug interactions
Dronedarone + Hydrocortisone
Severity: Minor
Dronedarone and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone is at most a weak CYP3A4 inducer, so a clinically meaningful drop in dronedarone exposure is not expected with typical doses. The legacy concern is largely theoretical.
What this interaction means in plain words
Dronedarone and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dronedarone belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 induction by hydrocortisone, which is not established as clinically relevant.
What to do
No routine change is needed; monitor rhythm control if high-dose corticosteroids are given for a long period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Hydrocortisone?
MediHelp rates the interaction as minor. Dronedarone and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrocortisone is at most a weak CYP3A4 inducer, so a clinically meaningful drop in dronedarone exposure is not expected with typical doses. The legacy concern is largely theoretical.
How serious is the interaction between Dronedarone and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor rhythm control if high-dose corticosteroids are given for a long period.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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