Drug interactions
Dronedarone + Infigratinib
Severity: Major
Dronedarone and Infigratinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone, a moderate CYP3A4 inhibitor, may increase infigratinib exposure and its adverse effects such as hyperphosphatemia, ocular toxicity and fatigue. Infigratinib is a CYP3A4 substrate, so higher levels are plausible.
What this interaction means in plain words
Dronedarone and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Dronedarone inhibits CYP3A4, reducing the metabolic clearance of infigratinib.
What to do
Prefer an alternative antiarrhythmic. If unavoidable, monitor closely for infigratinib toxicity and consider dose reduction per product labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dronedarone with Infigratinib?
MediHelp rates the interaction as major. Dronedarone and Infigratinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dronedarone, a moderate CYP3A4 inhibitor, may increase infigratinib exposure and its adverse effects such as hyperphosphatemia, ocular toxicity and fatigue. Infigratinib is a CYP3A4 substrate, so higher levels are plausible.
How serious is the interaction between Dronedarone and Infigratinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antiarrhythmic. If unavoidable, monitor closely for infigratinib toxicity and consider dose reduction per product labeling.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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